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2015-11-10 12:43:00

Research from ZIOC featured on the cover of Organometallics

Research from ZIOC featured on the cover of Organometallics

A recently published study gives a vivid example of unusual chemical reactivity associated with organogold complexes. Using modern physical methods and computational studies, the authors propose a reaction mechanism in which a molecule of acetic acid serves as a proton shuttle, transferring the hydrogen atom between the reaction centers.

 The study was carried out using both theoretical and experimental approaches. Dedicated labeling of the reagents allowed observation of molecular reorganizations. Variation of reaction conditions helped to estimate key factors governing the transformation. In addition, computational study of the reaction provided the models of certain intermediate steps, which were invisible for experimental investigation. The theoretical data obtained was in excellent agreement with the experiment, and the researchers propose a reaction mechanism in which a molecule of acetic acid serves as a proton shuttle, transferring the hydrogen atom between the reaction centers.

 As for now, the main goal is to "introduce gold catalysis as a valuable practical tool in fine organic chemistry, competitive with other transition metal catalysts", says Prof. Valentine P. Ananikov.

 More information: "Carboxylic Group-Assisted Proton Transfer in Gold-Mediated Thiolation of Alkynes." Organometallics.

 Online link: http://doi.org/10.1021/acs.organomet.5b00210

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Important events:

Professor Mario Pargliaro Lecturing at Zelinsky Institute Prof Mario Pagliaro (Palermo Italy) gave two talks on June 8th and 9th.
Selective In-Situ Metal Azide Reactions Alexey Sukhorukov, N. D. Zelinsky Institute of Organic Chemistry, Moscow, Russia, and colleagues studied the selective reactions of in-situ generated metal azides on N,N-bis(oxy)enamines. By combining readily generated bis(oxy)enamine substrates with sodium azide and one of a variety of metal salts (including Mg, Cu, Zn, Co, and Ni), the researchers showed that the metal cation selectively alters the mechanism to favor the formation of specific organoazide products.
On February 1st, Prof. Gleb Sukhorukov from the School of Engineering and Materials Science, Queen Mary, University of London, gave a lecture “Remote Controlled Delivery Nanosystems” at ZIOC.
“We can record up to one thousand spectra per day” Director of Zelinsky Institute about Devising New Molecules
Steep and Thorny Way of a Scientist in Russia Prof. Valentine Ananikov participated in the plenary panel discussion HR Challenge for the Society held in the framework of VII Russian National Congress of Young Scientists and Specialists on November 30 – December 1 2016 in MEPhI.
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