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2021-02-08 13:29:35

Researchers from the Zelinsky Institute have created a database of glycosyltransferases.

Glycosyltransferases are a proteomics object that is important for understanding the work of cells at the molecular level. Most of the known activities are predicted by bioinformatics methods, however, experimentally confirmed enzymatic activities are of great importance in glycological, immunochemical, and other studies. As part of the systematic work on the informatization of glycomics, scientists from ZIOC RAS (Laboratories № 21, 30, 35) developed a database of confirmed glycosyltransferases and placed in it almost all data published till 2020 on one of the most studied organisms of each of the three kingdoms (bacteria - E. coli, fungi - S. cerevisiae, plants - A. thaliana). About 2000 records include the activity of transferases, structures of donors, substrates, and carbohydrate products, references to genes and enzymes in other databases, taxonomic and bibliographic references, and the level of confidence in establishing activity. Data search by several criteria is freely available on the website http://csdb.glycoscience.ru/gt.html.

Source:

K.S. Egorova, N.S. Smirnova, Ph.V. Toukach CSDB_GT, a curated glycosyltransferase database with close-to-full coverage on three most studied non-animal species Glycobiology, 2021, accepted manuscript. DOI: 10.1093/glycob/cwaa107.

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The European Academy of Sciences (Academia Europaea) was founded in 1988. It unites about four thousand globally acknowledged experts in mathematics, medicine, natural sciences, humanities, law, economy, and social and political sciences from many countries of Europe. Among its members are also European scientists who live in other regions of the world. Currently, it includes seventy two Nobel laureates and it should be highlighted that many of them were elected to the Academy before winning the Prize.
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