Leninsky Prospect, 47, Moscow
Phone: +7 499 137-29-44
Fax: +7 499 135-53-28

Department of Unstable Molecules and Small-Sized Cyclic Compounds (comprised of 3 labs)

Head: Oleg M. Nefedov, Full Member of RAS (e-mail: nefedov@ioc.ac.ru, tel. +7(499)137-7390)

Department was established in 2004 on the basis of Laboratory of Carbene Chemistry and Small-Sized Cyclic Compounds, which had been founded in 1968 by Oleg M. Nefedov, Full Member of RAS, and includes three laboratories.

Research Areas

Using modern computational and experimental methods, comprehensive studies of the generation, structure, reactivity and chemical transformations of carbenes, their analogs, free radicals, and other unstable molecules with chemical bonds of unusual types, including multiple bonds E=X (E = Si, Ge; X = C, O, S).

Systematic research of reactions of diazo alkanes and diazo esters both as carbene precursors and as reagents of 1,3-dipolar cycloaddition to multiple bonds, as well as non-conventional diazo components in processes similar to azo coupling reactions.

Development of fundamentally new methods for the synthesis of important organofluorine and other synthons and organizing manufacture of the compounds with practically useful properties.

Main results

A method of the IR and UV spectroscopic investigation of intermediates and other unstable molecules at their low-temperature stabilization in inert matrices was developed.

A considerable contribution was made to the study of double bonds involving silicon and germanium atoms; in particular Si=C was observed experimentally and studied for the first time.

Original systematic research on the role of labile complexes and electron-transfer stages in reactions of carbene analogs and radicals was performed.

Novel synthetic methods for the production of fluoroarenes based on [1+2] and [2+2] cycloaddition of available fluorocarbenes, fluoroolefines and fluorodienes to unsaturated compounds was elaborated.

Regularities of catalytic cyclopropanation of a broad series of unsaturated compounds by aliphatic diazo compounds have been established. In particular a pioneering technology-compatible method of cyclopropanation of strained olefins under the conditions of simultaneous generation and catalytic destruction of diazomethane has been developed.

The capability of diazocyclopropane and its derivatives to enter into reactions both of 1,3-dipolar cycloaddition to unsaturated compounds and of azo coupling  with aromatic compounds and activated CH acids, with diazocyclopropane and cyclopropyldiazonium being trapped under direct nitrozation of cyclopropylamine with alkyl nitrites,  was discovered.

Manufacture of unique hydrocarbon fuel Cyclin and other high energy polycyclic hydrocarbons was set up in collaboration with other companies. The first Russian manufacture of synthetic pyrethroids was started. The studies on the directed synthesis and properties of new biologically active nitrogen-containing polycyclic compounds are in progress.


Important events:

Congratulations! Valentine Ananikov has been elected to Academia Europaea! The European Academy of Sciences (Academia Europaea) was founded in 1988. It unites about four thousand globally acknowledged experts in mathematics, medicine, natural sciences, humanities, law, economy, and social and political sciences from many countries of Europe. Among its members are also European scientists who live in other regions of the world. Currently, it includes seventy two Nobel laureates and it should be highlighted that many of them were elected to the Academy before winning the Prize.
Professor Mario Pargliaro Lecturing at Zelinsky Institute Prof Mario Pagliaro (Palermo Italy) gave two talks on June 8th and 9th.
Selective In-Situ Metal Azide Reactions Alexey Sukhorukov, N. D. Zelinsky Institute of Organic Chemistry, Moscow, Russia, and colleagues studied the selective reactions of in-situ generated metal azides on N,N-bis(oxy)enamines. By combining readily generated bis(oxy)enamine substrates with sodium azide and one of a variety of metal salts (including Mg, Cu, Zn, Co, and Ni), the researchers showed that the metal cation selectively alters the mechanism to favor the formation of specific organoazide products.
On February 1st, Prof. Gleb Sukhorukov from the School of Engineering and Materials Science, Queen Mary, University of London, gave a lecture “Remote Controlled Delivery Nanosystems” at ZIOC.
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