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2015-12-09 12:05:00

Interview for The Medicine Maker

A popular edition The Medicine Maker has published theinterview A Soluble Solution for Drug Delivery with ZIOC researchers who discuss the efficacy of ionic liquid applications in pharmaceutics.

The interest of The Medicine Maker to ionic liquids originated from the ZIOC research communicated in the paper "Cytotoxic activity of salicylic acid-containing drug models with ionic and covalent binding" published in Medicinal Chemistry Letters of the American Chemical Society. It describes the use of salicylic acid, a known anti-inflammatory agent, as a drug model. Salicylic acid molecules had been incorporated into ionic liquids and solubility and biological activity in respect of human fibroblasts and colorectal adenocarcinoma cells were studied. Salicylic acid retained its activity in the ionic liquid and exhibited higher solubility in water as compared to pure salicylic acid. The research proves that ionic-liquid drugs with “dual action” show promise in combined therapy.

The paper "Cytotoxic activity of salicylic acid-containing drug models with ionic and covalent binding" (Egorova K. S., Seitkalieva M. M., Posvyatenko A. V., Khrustalev V. N., and Ananikov V. P.) was published in ACS Med. Chem. Lett., 2015, DOI: 10.1021/acsmedchemlett.5b00258link

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Important events:

Professor Mario Pargliaro Lecturing at Zelinsky Institute Prof Mario Pagliaro (Palermo Italy) gave two talks on June 8th and 9th.
Selective In-Situ Metal Azide Reactions Alexey Sukhorukov, N. D. Zelinsky Institute of Organic Chemistry, Moscow, Russia, and colleagues studied the selective reactions of in-situ generated metal azides on N,N-bis(oxy)enamines. By combining readily generated bis(oxy)enamine substrates with sodium azide and one of a variety of metal salts (including Mg, Cu, Zn, Co, and Ni), the researchers showed that the metal cation selectively alters the mechanism to favor the formation of specific organoazide products.
On February 1st, Prof. Gleb Sukhorukov from the School of Engineering and Materials Science, Queen Mary, University of London, gave a lecture “Remote Controlled Delivery Nanosystems” at ZIOC.
“We can record up to one thousand spectra per day” Director of Zelinsky Institute about Devising New Molecules
Steep and Thorny Way of a Scientist in Russia Prof. Valentine Ananikov participated in the plenary panel discussion HR Challenge for the Society held in the framework of VII Russian National Congress of Young Scientists and Specialists on November 30 – December 1 2016 in MEPhI.
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