Leninsky Prospect, 47, Moscow
Phone: +7 499 137-29-44
Fax: +7 499 135-53-28

Laboratory of Functional Organic Compounds (N8)

Head: Alexander D. Dilman, DSc (e-mail: dilmanioc.ac.ru, tel. +7(499)137-68-29)

The laboratory was established in 2011 on the basis of Laboratory of Chemistry of Nitro Compounds

Research Group of DSc A.D. Dilman

Website of Alexander Dilman’s Research Group - click here

Research Areas

Synthesis of organofluorine compounds

Methodology of the organic synthesis using fluorine, silicon and boron compounds

Development of C-C bond forming reactions

Main Results

Development of new nucleophilic fluoroalkylation methods

Research Group of Prof. S.L. Ioffe

Research Areas

Chemistry of aliphatic nitro compounds (ANCs) and their derivatives (acyclic and cyclic nitronates), and the  targeted synthesis of functional organic compounds from ANC.

Main Results

A novel strategy for the application of ANCs in the directed organic synthesis based on their silylation process has been proposed. A convenient synthesis of known highly potent Rolipram and Cilomilast analogs sourced from available precursors has been developed. The suggested synthetic strategy is considerably more efficient as compared to previous syntheses of these compounds developed by GlaxoSmithKline. The first synthesis of 1,4,6,10-tetraazaadamantanes – a novel class of heterocage compounds isomeric to Urotropin – has been accomplished.

 ANC silylation is a unique process that has no close analogies in organic chemistry. It is kind of a redox process, i.e. a sequence of ANC successive transformations, in which, under the action of mediators (silylating agents), the nitro group is gradually reduced whereas the hydrocarbon skeleton is oxidized. In these transformations, protons are consecutively eliminated from α, β and γ carbon atoms of ANCs. Corresponding nitronates, N,N-bis-oxyiminium cations, nitrosoacetals, and conjugated en-oximes are intermediates in the silylation process.

The suggested approach allows one to transform a small set of available ANCs into a variety of polyfunctional derivatives using silylation as a key procedure. Many of these transformations proceed with high regio- and stereoselectivity.

Conferences organized by Institute:

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Important events:

Professor Mario Pargliaro Lecturing at Zelinsky Institute Prof Mario Pagliaro (Palermo Italy) gave two talks on June 8th and 9th.
Selective In-Situ Metal Azide Reactions Alexey Sukhorukov, N. D. Zelinsky Institute of Organic Chemistry, Moscow, Russia, and colleagues studied the selective reactions of in-situ generated metal azides on N,N-bis(oxy)enamines. By combining readily generated bis(oxy)enamine substrates with sodium azide and one of a variety of metal salts (including Mg, Cu, Zn, Co, and Ni), the researchers showed that the metal cation selectively alters the mechanism to favor the formation of specific organoazide products.
On February 1st, Prof. Gleb Sukhorukov from the School of Engineering and Materials Science, Queen Mary, University of London, gave a lecture “Remote Controlled Delivery Nanosystems” at ZIOC.
“We can record up to one thousand spectra per day” Director of Zelinsky Institute about Devising New Molecules
Steep and Thorny Way of a Scientist in Russia Prof. Valentine Ananikov participated in the plenary panel discussion HR Challenge for the Society held in the framework of VII Russian National Congress of Young Scientists and Specialists on November 30 – December 1 2016 in MEPhI.
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