Head: Oleg A. Rakitin, Prof., DSc (Chem.)(e-mail: orakitinioc.ac.ru, tel. +7(499) 135-5327)
The laboratory was founded in 1995 on the basis of a part of Laboratory of Nitrogen-Containing Compounds and since then it has been headed by its current leader.
Synthesis and chemical properties of novel chemical polysulfur- and sulphur-nitrogen heterocyclic compounds, both aromatic and antiaromatic, as well as systems with extended conjugation.
Search of components for nonlinear optical materials, viz. electron-rich liquid crystalline substances, organic conductors, and magnetic materials.
Development of routes for the preparation of polysulfur heterocycles, viz. 1,2,3,4,5-pentathiepines, 1,2-dithioles and 1,2,3-dithiazoles as potential biologically active compounds, particularly antitumour agents.
Synthesis of new sulfur-containing heterocyclic systems with potential anticancer activity based on 1,2-dithiols.
Design of heterocyclic thiazyl radicals and anion-radicals and their selenium and tellurium analogs as novel functional materials – magnetic, magnetically bistable, conducting, and superconducting.
Synthesis of new sulfur heterocyclic systems with anticancer activity from 1,2-dithioles.
A discovery of novel pathways to the synthesis of polysulfur-nitrogen heterocycles containing several sulfur atoms and a nitrogen atom on the basis of a reaction of a complex of sulfur monochloride with a nitrogen-containing base; synthesis of several novel heterocyclic systems, including 1,2- and 1,4-thiazines, thiophenes, monocyclic and fused 1,2-dithioles and 1,2,3-dithiazoles, 1,2,3,4,5-pentathiepins, 1,2,3,4,5,6,7-heptathiocans, etc. with anticancer, antimicrobial and antifungal activity.
Synthesized 1,2,3,4,5-pentathiepines have been studied as cathodic materials for storage batteries; fused 1,4-ditynes have been proposed as multi-purpose components for photoreceptors.
A classification of transformations of organic substrates with sulfur monochloride has been proposed. It enabled not only a systematization of previously found reactions but also direct planning of a selective synthesis of new sulfur-containing heterocyclic systems from acyclic fragments.
Methods to prepare novel heterocyclic systems such as pyrrolo [2', 1': 3,4] pyrazine [2,1-b] [1,3] thiazines, 1,2-dithiol-3-ilidenopyridines and 1,2-dithiol-3-ilidenopirazines, imino-1,3-ditytanes, imino-1,3-thiazitydines, etc. based on transformations of 1,2-dithiols have been developed.