Leninsky Prospect, 47, Moscow
Phone: +7 499 137-29-44
Fax: +7 499 135-53-28

Laboratory of Polysulphur-Nitrogen Heterocycles (N31)

Head: Oleg A. Rakitin, Prof., DSc (Chem.)(e-mail: orakitinioc.ac.ru, tel. +7(499) 135-5327)

The laboratory was founded in 1995 on the basis of a part of Laboratory of Nitrogen-Containing Compounds and since then it has been headed by its current leader.

Research Areas

Synthesis and chemical properties of novel chemical polysulfur- and sulphur-nitrogen heterocyclic compounds, both aromatic and antiaromatic, as well as systems with extended conjugation.

Search of components for nonlinear optical materials, viz. electron-rich liquid crystalline substances, organic conductors, and magnetic materials.

Development of routes for the preparation of polysulfur heterocycles, viz. 1,2,3,4,5-pentathiepines, 1,2-dithioles and 1,2,3-dithiazoles as potential biologically active compounds, particularly antitumour agents.

Synthesis of new sulfur-containing heterocyclic systems with potential anticancer activity based on 1,2-dithiols.

Design of heterocyclic thiazyl radicals and anion-radicals and their selenium and tellurium analogs as novel functional materials – magnetic, magnetically bistable, conducting, and superconducting.

Synthesis of new sulfur heterocyclic systems with anticancer activity from 1,2-dithioles.

Main Results

A discovery of novel pathways to the synthesis of polysulfur-nitrogen heterocycles containing several sulfur atoms and a nitrogen atom on the basis of a reaction of a complex of sulfur monochloride with a nitrogen-containing base; synthesis of several novel heterocyclic systems, including 1,2- and 1,4-thiazines, thiophenes, monocyclic and fused 1,2-dithioles and 1,2,3-dithiazoles, 1,2,3,4,5-pentathiepins, 1,2,3,4,5,6,7-heptathiocans, etc. with anticancer, antimicrobial and antifungal activity.

Synthesized 1,2,3,4,5-pentathiepines have been studied as cathodic materials for storage batteries; fused 1,4-ditynes have been proposed as multi-purpose components for photoreceptors.

A classification of transformations of organic substrates with sulfur monochloride has been proposed. It enabled not only a systematization of previously found reactions but also direct planning of a selective synthesis of new sulfur-containing heterocyclic systems from acyclic fragments.

Methods to prepare novel heterocyclic systems such as pyrrolo [2', 1': 3,4] pyrazine [2,1-b] [1,3] thiazines, 1,2-dithiol-3-ilidenopyridines and 1,2-dithiol-3-ilidenopirazines, imino-1,3-ditytanes, imino-1,3-thiazitydines, etc. based on transformations of 1,2-dithiols have been developed.

Лаборатория 31

Conferences organized by Institute:

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Important events:

Professor Mario Pargliaro Lecturing at Zelinsky Institute Prof Mario Pagliaro (Palermo Italy) gave two talks on June 8th and 9th.
Selective In-Situ Metal Azide Reactions Alexey Sukhorukov, N. D. Zelinsky Institute of Organic Chemistry, Moscow, Russia, and colleagues studied the selective reactions of in-situ generated metal azides on N,N-bis(oxy)enamines. By combining readily generated bis(oxy)enamine substrates with sodium azide and one of a variety of metal salts (including Mg, Cu, Zn, Co, and Ni), the researchers showed that the metal cation selectively alters the mechanism to favor the formation of specific organoazide products.
On February 1st, Prof. Gleb Sukhorukov from the School of Engineering and Materials Science, Queen Mary, University of London, gave a lecture “Remote Controlled Delivery Nanosystems” at ZIOC.
“We can record up to one thousand spectra per day” Director of Zelinsky Institute about Devising New Molecules
Steep and Thorny Way of a Scientist in Russia Prof. Valentine Ananikov participated in the plenary panel discussion HR Challenge for the Society held in the framework of VII Russian National Congress of Young Scientists and Specialists on November 30 – December 1 2016 in MEPhI.
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