Zelinsky Institute researchers’ work was put on the main page of international publisher

The results of research, conducted in laboratory №19 Zelinsky Institute of Organic Chemistry, were mentioned on the main page of Thieme Chemistry publisher. The study is devoted to the development of methods of previously unavailable 1-substituted semithioglycolurils — new perspective scaffolds for organic synthesis.

Glycolurils are organic compounds featuring two cyclic urea groups joined across the same two-carbon chain. The first publication describing their synthesis dates back to 1870 and was authored by Hugo Schiff. Semithioglycolurils incorporate one sulfur atom that replaces one of the two carbonyl oxygens, and their chemistry is less developed than that of the parent urea-type compounds. In the published manuscript, two simple approaches to previously unavailable synthetically 1-substituted semithioglycolurils were developed. These methods include cyclocondensation of 1-substituted ureas with 4,5-dihydroxy- or 4,5-dimethoxyimidazolidine-2-thione or glyoxal, followed by the reaction of the resulting 1-substituted 4,5-dihydroxyimidazolidine-2-ones with HSCN in a two-step one-pot procedure. This research made 1-substituted semithioglycolurils available class of organic compounds, which will make possible their application in the synthesis of new heterocyclic structures.

Source: Thieme Chemistry