The researcher from Zelinsky Institute reviewed recent achievements in the field of reductive amination reactions involving nitrocompounds

The reductive amination of carbonyl compounds with primary amines is a well-known synthetic methodology for the selective synthesis of asymmetrically substituted secondary and tertiary amines. From the point of view of industrial and green chemistry, the combination of reductive amination with the synthesis of primary amines in a single catalytic process is quite attractive. One of the most available and inexpensive precursors of primary amines in such reactions are nitro compounds. The direct reductive coupling of nitro compounds with aldehydes/ketones for the preparation of secondary and tertiary amines has been known since the 1940s. However, in the last decade, a great progress in this field was made due to developed highly efficient and selective non-noble metals-based catalysts.

The published review is devoted to the recent achievements in the methodology of reductive amination with nitro compounds. Particular attention was paid to the use of these transformations in the synthesis of biologically active amines and heterocycles.

Source:

A. Yu. Sukhorukov, Catalytic Reductive Amination of Aldehydes and Ketones With Nitro Compounds: New Light on an Old Reaction, Chem. Front., 2020, DOI: 10.3389/fchem.2020.00215.