Scientists from the Zelinsky Institute published a review on the synthesis of bioactive nitro compounds
The synthesis and study of biologically active compounds remains one of the most important and developing areas of organic and medicinal chemistry. Both natural and synthetic aromatic nitro compounds represent a wide class of organic molecules with a wide variety of biological activities. Many papers are published annually on new methods for the synthesis of bioactive aromatic nitro compounds, their metabolism and toxicity.
Scientists from the Laboratory of Aromatic Nitrogen-Containing Compounds have published a review on methods for the synthesis of both known and new aromatic and heteroaromatic nitrocompounds, covering the period from 2010 to the present. An analysis of the literature has shown that the chemistry of nitro compounds is actively developing: syntheses of already known compounds are being improved and optimized, new syntheses are being published, and new nitro-containing agents are being developed. Thus, today aromatic nitro compounds are used not only as energetic compounds, but are also increasingly used in medicine.
Maxim Bastrakov and Alexey Starosotnikov Recent Progress in the Synthesis of Drugs and Bioactive Molecules Incorporating Nitro(het)arene Core. Pharmaceuticals 2022, 15, 705. DOI: 10.3390/ph15060705.