ZIOC researchers published a review on the use of quaternary ammonium compounds in the fight against resistant bacterial colonies.
The vast majority of pathogens are found in the environment in the form of surface-bound microbial communities called biofilms. The unique protective properties and high stability of biofilms lead to the ineffectiveness of many traditional treatments and contribute to serious economic losses in various industries. A comprehensive assessment of the activity of new antimicrobial agents at each stage of biofilm formation is necessary to achieve progress and transfer developments to real clinical practice. Quaternary ammonium compounds (QACs) play a key role in many methods of treatment and prevention of biofilm formation, based both on the use of individual antibacterial agents and on combined technologies.
Researchers from several laboratories of the Zelinsky Institute published a review summarizing the literature data on the effectiveness of commercially available and recently synthesized QACs, as well as complementary treatment methods based on them. Methods for the development and application of antimicrobial coatings that prevent the formation of biofilms on various surfaces over time are discussed as an important area.
Evgeniya A. Saverina, Nikita A. Frolov, Olga A. Kamanina, Vyacheslav A. Arlyapov, Anatoly N. Vereshchagin, Valentine P. Ananikov From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs) // ACS Infect. Dis. 2023, accepted manuscript. DOI: 10.1021/acsinfecdis.2c00469.