Researchers of the Zelinsky Institute have obtained promising compounds with high fungicidal activity

Parasitic fungi are quite dangerous to humans and domestic animals, and damage crops and ornamental plants. Invasive fungal infections are increasingly recognized in clinics as life-threatening. Fungal infections affect more than 300 million people, resulting in more than 1.3 million deaths per year. In addition, plant diseases caused by parasitic fungi are an important factor in agricultural production, causing significant crop losses. Antifungal resistance is a major problem and requires constant updating of the drugs and agrochemicals used. In this regard, the development of new effective fungicides is an urgent task of science at the present time.

As part of ongoing research by scientists from the Laboratory of Nitrogen-Containing Compounds of the Zelinsky Institute on the search for fungicides among thioglycolurils derivatives, in one of their latest works, they managed to synthesize a number of S-alkyl-substituted thioglycolurils by alkylation of the corresponding thioglycolurils with haloalkanes. The resulting compounds were tested for fungicidal activity against six phytopathogenic fungi from different taxonomic classes, as well as against two pathogenic yeast species. Several synthesized structures were comparable or even superior in activity to the commercial fungicide triadimefon. It was also shown that the inhibitory activity of the studied compounds rose with an increase in the length of the alkyl chain at the sulfur atom. Further research in this direction will be focused on evaluating the fungicidal activity of S-alkylthioglycolurils in vivo and elucidating the mechanism of their action.
 

Source:

Ekaterina E. Vinogradova, Anna L. Alekseenko, Sergey V. Popkov, Natalya G. Kolotyrkina, Angelina N. Kravchenko, Galina A. Gazieva Synthesis and Evaluation on the Fungicidal Activity of S-Alkyl Substituted Thioglycolurils // Int. J. Mol. Sci. 2023, 24, 5756. DOI: 10.3390/ijms24065756.