РУС ENG
Министерство науки и высшего образования Российской Федерации
Российская Академия Наук

Laboratory of carbohydrates and biocides named after Academician N. K. Kochetkov (№ 21)

D.Sc. Vereshchagin Anatoly Nikolaevich
Chief: D.Sc. Vereshchagin Anatoly Nikolaevich
ORCID: 0000-0001-8675-4943 Researcher ID: M-4057-2016 h-index = 23
Main directions of research

Bacterial Polysaccharides Study Group

  • Structure and application of cell wall and capsule polysaccharides of medically important bacteria (Escherichia, Shigella, Yersinia, Enterobacter, Acinetobacter) and phytopathogenic microorganisms (Pseudomonas, Pantoea, Pectobacterium).
  • Degradation mechanisms of bacterial polysaccharides by bacteriophage depolymerases — potential antibacterial agents.
  • Synthesis of conjugates based on oligosaccharide fragments of bacterial polysaccharides as potential vaccines.
  • Development of new methods for the structural analysis of natural complex carbohydrates.

 

Glycoinformatics group

The group's efforts are aimed on enriched carbohydrate science with all the power of modern computer technologies, providing scientists with easy access to data, creating services for generalizing knowledge, modeling glycomic objects and predicting their properties, and developing the information technologies necessary for this. Current areas of the work:

 

  • Glycoinformatics platform “Carbohydrate Structure Database” [http://csdb.glycoscience.ru], as the basis for web services and a complete, regularly updated curated database of natural carbohydrates of prokaryotic, fungal and vegetable origin;
  • Сurated glycosyltransferase database [http://csdb.glycoscience.ru/gt.html] for the three most studied species of bacteria, plants and fungi;
  • Сhemical shift model, a new approach to spectrum prediction, 1D and 2D NMR simulation service for carbohydrates and their derivatives with unprecedented average accuracy of 0.6 (13C) and 0.07 (1H) ppm. (GODDESS [http://csdb.glycoscience.ru/goddess.html]);
  • Model and web service for predicting the primary structure of carbohydrates from NMR spectra and other easily obtained experimental data (GRASS [http://csdb.glycoscience.ru/grass.html]).

 

Biocide Study Group

  • Synthesis of new cationic biocides, in particular quaternary ammonium compounds (QACs), which have broad antibacterial, antifungal and antiviral effects;

  • Quantitative structure–activity relationship study of new type QACs, directed synthesis of target molecules;

 

  • Creation of new antiseptic formulations based on hit-compounds.

 

Selected publications of recent years
Institute News
Researchers of the Zelinsky Institute have proposed a reagent for the photocatalytic activation of the carbon-halogen bond Researchers of the Zelinsky Institute have proposed a reagent for the photocatalytic activation of the carbon-halogen bond
The breaking of the carbon-halogen bond is quite widely used to generate organic carbon-centered radicals. Among the alkyl halides, chlorine derivatives…
ZIOC researchers published a review on the use of quaternary ammonium compounds in the fight against resistant bacterial colonies. ZIOC researchers published a review on the use of quaternary ammonium compounds in the fight against resistant bacterial colonies.
The vast majority of pathogens are found in the environment in the form of surface-bound microbial communities called biofilms. The unique protective properties…
Scientists of the Zelinsky Institute studied the reaction of diphenyl disulfide with Lappert's germylene Scientists of the Zelinsky Institute studied the reaction of diphenyl disulfide with Lappert's germylene
The use of transition metals catalysis provoked the rapid development of organic chemistry in the second half of the 20th century and continues to play…
The research on the photochemistry of diarylethenes is continued in the Zelinsky Institute The research on the photochemistry of diarylethenes is continued in the Zelinsky Institute
In recent decades, the photochemistry of diarylethenes and their derivatives has been actively developing. One of the areas of development of this area…
ZIOC scientists synthesized new water-soluble substances with high antiproliferative activity ZIOC scientists synthesized new water-soluble substances with high antiproliferative activity
Nitrogen- and sulfur-containing heterocyclic structures have a wide range of biological activity and are part of a large number of drugs. Among these compounds,…
A framework for analyzing real-time electron microscopy data was developed in the ZIOC A framework for analyzing real-time electron microscopy data was developed in the ZIOC
Electron microscopy is one of the most widely used methods for studying the structure of materials, biological objects, and complex chemical systems of…

Laboratory of carbohydrates and biocides named after Academician N. K. Kochetkov (№ 21) ORCID: 0000-0001-8675-4943 Researcher ID: M-4057-2016 h-index = 23 ST LUCE https://zioc.ru/ 5 100 .00 RUB http://schema.org/InStock