РУС ENG
Министерство науки и высшего образования Российской Федерации
Российская Академия Наук

Laboratory of Nitro Aromatic Compounds (N18)

DSc Igor L. Dalinger
Chief: DSc Igor L. Dalinger
Main directions of research

Head: DSc Igor L. Dalinger, (e-mail: dalingerioc.ac.ru, tel. +7(499)135-6340)

The laboratory was established in 1990 on the basis of Laboratory of Aliphatic Compounds headed by Prof. A.A. Fainsilberg.

Research areas

Developing fundamental grounds of chemistry of aromatic and N-heterocyclic nitro compounds with a view to create synthetic methodologies for new potential components of energetic materials, biologically active compounds, polymer compositions, novel dyes, and reagents – chemical building blocks.

Main results

In the framework of the TNT conversion (recycling) program, methods and technologies were developed for the preparation of polymers, dyes, etc. from TNT and its transformation products.

Factors that determine nucleophilic substitution in nitro arenes were identified, which allowed directed substitution of nitro groups and introduction of preset substituents to molecules of TNT, sym-trinitrobenzene and their derivatives.

Joint research projects with IPCP RAS, R&D Institute KRISTALL, INEOS RAS and Mendeleev UCTR resulted in:

  • flexible and rigid polyurethane foams with improved operating parameters;
  • novel condensation monomers (nitro group reduction products) and thermally stable polyimides and polyamides on their basis with improved performance, including solubility, with potential applications in microelectronics;
  • a number of condensation monomers and protogenic polymers bearing sulfoxylic groups able to form fuel cell membranes; and
  • a representative series of dyes with a wide range of coloring and high affinity suitable for coloring of wool, synthetic fibers and wood.

A new intramolecular rearrangement of O-arylketoximes was found to lead to the previously unknown type of substituted indoles with hydroxyl and nitro groups. The compounds possess high antifungal activity towards a wide spectrum of phytopathogenic fungi and towards clinical isolates of human fungi (in collaboration with Mendeleev UCTR, IBMC RAMS, and NACFF).

A new methodology for the synthesis of a wide range of polycyclic benzo-fused N-heterosystems was developed on the basis of nitro arenes, including TNT and its transformation products. The general approaches are: nucleophilic aromatic substitution of hydrogen (SNH), nitro and other groups, condensation of hydride σÍ-adducts and previously unknown pericyclic [3+2]-cycloaddition reactions of nitro arenes.

As a contribution of Laboratory to the international program on the creation of HIV-1 integrase inhibitors, a new type of inhibitors was found — nitro benzofurazans and -furoxans with promising activity relevant for further investigations.

A method for the synthesis of fully C-nitrated 3,4,5-trinitropyrazole was elaborated. This compound is a unique building block that allows changing the nucleophilic substitution direction in terms of reaction conditions.

General regularities of nucleophilic substitution in polynitro pyrazoles were found out. As a result, a universal method of directed functionalization of the pyrazole nucleus was created based on inter- and intramolecular nucleophilic substitution in polynitro pyrazoles. Utilization of the approach in chemistry of energetic materials enabled a synthesis of a number of novel efficient energy-intensive pyrazole derivatives, in particular low sensitive.

Лаборатория 18

Institute News
During a joint Russian-Chinese study, an organic solar battery with an efficiency > 18% was created During a joint Russian-Chinese study, an organic solar battery with an efficiency > 18% was created
Organic solar cells (OSC) are one of the most promising renewable energy technologies due to their low cost, flexibility and lightness, as well as the…
Scientists of the Zelinsky Institute published a review on radical reactions of the functionalization of heterocycles with heteroatom-centered radicals Scientists of the Zelinsky Institute published a review on radical reactions of the functionalization of heterocycles with heteroatom-centered radicals
In the last decade, free radicals have found a wide application in the functionalization of unsaturated compounds such as alkenes, alkynes, and arenes…
ZIOC researchers have developed a general method for the synthesis of important organophosphorus building blocks ZIOC researchers have developed a general method for the synthesis of important organophosphorus building blocks
Organophosphorus compounds are widely used in medicine and agriculture. Over the past decades, great progress has been made in the field of carbon-phosphorus…
Researchers of the ZIOC published a review on the use of microwave radiation for the synthesis of heterogeneous catalysts and catalytic hydrogenation processes Researchers of the ZIOC published a review on the use of microwave radiation for the synthesis of heterogeneous catalysts and catalytic hydrogenation processes
Currently, one of the promising methods for obtaining heterogeneous catalysts is microwave synthesis, the undoubted advantages of which are uniform heat…
The search for new fluorescent dyes for the creation of organic light-emitting diodes continues at the ZIOC The search for new fluorescent dyes for the creation of organic light-emitting diodes continues at the ZIOC
At the moment, π-conjugated organic molecules have attracted much attention from scientists due to their ability to optimize light absorption, light emission,…
Scientists from the ZIOC developed the concept of 4D catalysis and were able to trace the evolution of specific particles of a metal catalyst during the catalytic process Scientists from the ZIOC developed the concept of 4D catalysis and were able to trace the evolution of specific particles of a metal catalyst during the catalytic process
Catalysis by supported metal nanoparticles is of key importance for modern organic synthesis in science and industry. The properties of these catalysts…

Laboratory of Nitro Aromatic Compounds (N18) Head: DSc Igor L. Dalinger, (e-mail: dalingerioc.ac.ru, tel. +7(499)135-6340) The laboratory was established in 1990 on the basis of Laboratory of Aliphatic Compounds headed by Prof. A.A. Fainsilberg. Research areas Developing fundamental grounds of chemistry of aromatic and N-heterocyclic nitro compounds… ST LUCE https://zioc.ru/ 5 100 .00 RUB http://schema.org/InStock