Leninsky Prospect, 47, Moscow
Phone: +7 499 137-29-44
Fax: +7 499 135-53-28

Laboratory of Nitro Aromatic Compounds (N18)

Head: DSc Igor L. Dalinger, (e-mail: dalingerioc.ac.ru, tel. +7(499)135-6340)

The laboratory was established in 1990 on the basis of Laboratory of Aliphatic Compounds headed by Prof. A.A. Fainsilberg.

Research areas

Developing fundamental grounds of chemistry of aromatic and N-heterocyclic nitro compounds with a view to create synthetic methodologies for new potential components of energetic materials, biologically active compounds, polymer compositions, novel dyes, and reagents – chemical building blocks.

Main results

In the framework of the TNT conversion (recycling) program, methods and technologies were developed for the preparation of polymers, dyes, etc. from TNT and its transformation products.

Factors that determine nucleophilic substitution in nitro arenes were identified, which allowed directed substitution of nitro groups and introduction of preset substituents to molecules of TNT, sym-trinitrobenzene and their derivatives.

Joint research projects with IPCP RAS, R&D Institute KRISTALL, INEOS RAS and Mendeleev UCTR resulted in:

  • flexible and rigid polyurethane foams with improved operating parameters;
  • novel condensation monomers (nitro group reduction products) and thermally stable polyimides and polyamides on their basis with improved performance, including solubility, with potential applications in microelectronics;
  • a number of condensation monomers and protogenic polymers bearing sulfoxylic groups able to form fuel cell membranes; and
  • a representative series of dyes with a wide range of coloring and high affinity suitable for coloring of wool, synthetic fibers and wood.

A new intramolecular rearrangement of O-arylketoximes was found to lead to the previously unknown type of substituted indoles with hydroxyl and nitro groups. The compounds possess high antifungal activity towards a wide spectrum of phytopathogenic fungi and towards clinical isolates of human fungi (in collaboration with Mendeleev UCTR, IBMC RAMS, and NACFF).

A new methodology for the synthesis of a wide range of polycyclic benzo-fused N-heterosystems was developed on the basis of nitro arenes, including TNT and its transformation products. The general approaches are: nucleophilic aromatic substitution of hydrogen (SNH), nitro and other groups, condensation of hydride σÍ-adducts and previously unknown pericyclic [3+2]-cycloaddition reactions of nitro arenes.

As a contribution of Laboratory to the international program on the creation of HIV-1 integrase inhibitors, a new type of inhibitors was found - nitro benzofurazans and -furoxans with promising activity relevant for further investigations.

A method for the synthesis of fully C-nitrated 3,4,5-trinitropyrazole was elaborated. This compound is a unique building block that allows changing the nucleophilic substitution direction in terms of reaction conditions.

General regularities of nucleophilic substitution in polynitro pyrazoles were found out. As a result, a universal method of directed functionalization of the pyrazole nucleus was created based on inter- and intramolecular nucleophilic substitution in polynitro pyrazoles. Utilization of the approach in chemistry of energetic materials enabled a synthesis of a number of novel efficient energy-intensive pyrazole derivatives, in particular low sensitive.

Лаборатория 18

Conferences organized by Institute:

All Conferences »

Important events:

Congratulations! Valentine Ananikov has been elected to Academia Europaea! The European Academy of Sciences (Academia Europaea) was founded in 1988. It unites about four thousand globally acknowledged experts in mathematics, medicine, natural sciences, humanities, law, economy, and social and political sciences from many countries of Europe. Among its members are also European scientists who live in other regions of the world. Currently, it includes seventy two Nobel laureates and it should be highlighted that many of them were elected to the Academy before winning the Prize.
Professor Mario Pargliaro Lecturing at Zelinsky Institute Prof Mario Pagliaro (Palermo Italy) gave two talks on June 8th and 9th.
Selective In-Situ Metal Azide Reactions Alexey Sukhorukov, N. D. Zelinsky Institute of Organic Chemistry, Moscow, Russia, and colleagues studied the selective reactions of in-situ generated metal azides on N,N-bis(oxy)enamines. By combining readily generated bis(oxy)enamine substrates with sodium azide and one of a variety of metal salts (including Mg, Cu, Zn, Co, and Ni), the researchers showed that the metal cation selectively alters the mechanism to favor the formation of specific organoazide products.
On February 1st, Prof. Gleb Sukhorukov from the School of Engineering and Materials Science, Queen Mary, University of London, gave a lecture “Remote Controlled Delivery Nanosystems” at ZIOC.
All Events »