As part of research on the complete synthesis of bioactive pyrrolidine derivatives, the scientists of laboratory № 9 of ZIOC RAS developed an asymmetric full synthesis of Merck12-a2-2, its epimer at the C-12 position and their enantiomers with a total yield of 5% at 10 stages
Despite the successful use of antibiotics and antifungal drugs in modern medicine, rising resistance to them has been increasingly observed in recent years. In this regard, there is a real need for innovative solutions aimed at stopping this problem and reducing the burden of infection resistant to existing drugs.
Researchers from laboratory № 30 of ZIOC RAS succeeded in developing an efficient and atom-economical approach to the hydrothiolation of cyclopropylacetylenes. As a result, highly functionalized vinyl sulfides of the Markovnikov type were obtained.
As part of the research by scientists of laboratory № 8 of Zelinsky Institute in the field of organofluorine chemistry, the process of fluoroalkylation-thiolation of alkenes under blue light irradiation was developed.
The review, which was published by researchers of laboratory №13 of Zelinsky Institute, is devoted to recent achievements in the field of oxidative sulfonylation of multiple bonds with sulfonyl hydrazides, sulfinic acids and their salts, which are used as sulfonylation reagents in such transformations.
Researchers from laboratory № 13 of Zelinsky Institute demonstrated that the generated from N-hydroxyphthalimide in undivided electrochemical cell radicals did not decompose, but selectively entered into an oxidative coupling with vinyl azides.
The research carried out in laboratory № 13 of Zelinsky Institute in collaboration with colleagues from the National Center for Genetic Engineering and Biotechnology (Thailand) and the Macau University of Science and Technology (China), is featured on the cover of the top-rated international journal ChemMedChem.
Researchers from Laboratory № 22 of the Institute of Organic Chemistry have developed an easy synthetic route to unsymmetrically substituted N-aryl oxalamides using inexpensive and available 2,2'-biphenyldiamines, 2-chloroacetamides, sulfur, and water as starting compounds.
Over the last few decades, molecules representing a combination of aromatic nitrogen-oxygen heterocycles and energy functional groups, such as NO2, N3, NHNO2, N=N and N=N(O), as substituents have attracted considerable interest in the search for new explosives. Researchers from Laboratody № 19 of Zelinsky Institute are actively involved in the research in this direction.
The European Academy of Sciences (Academia Europaea) was founded in 1988. It unites about four thousand globally acknowledged experts in mathematics, medicine, natural sciences, humanities, law, economy, and social and political sciences from many countries of Europe. Among its members are also European scientists who live in other regions of the world. Currently, it includes seventy two Nobel laureates and it should be highlighted that many of them were elected to the Academy before winning the Prize.
Alexey Sukhorukov, N. D. Zelinsky Institute of Organic Chemistry, Moscow, Russia, and colleagues studied the selective reactions of in-situ generated metal azides on N,N-bis(oxy)enamines. By combining readily generated bis(oxy)enamine substrates with sodium azide and one of a variety of metal salts (including Mg, Cu, Zn, Co, and Ni), the researchers showed that the metal cation selectively alters the mechanism to favor the formation of specific organoazide products.